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Product Name: |
Benzyl benzoate |
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Synonyms: |
N-tert-Butoxycarbonyl-L-aspartic Acid αBenzyl benzoate ReagentPlus(R), >=99.0%;Benzyl benzoate Vetec(TM) reagent grade, 98%;Benzoic acid benzyl ester≥ 99% (GC);VANZOATE(R);VENZONATE(R);Benylate;Benzyl alcohol benzoic ester |
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CAS: |
120-51-4 |
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MF: |
C14H12O2 |
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MW: |
212.24 |
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EINECS: |
204-402-9 |
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Product Categories: |
Solvent;INORGANIC & ORGANIC CHEMICALS;Chemical -;Aromatic Esters;Piperazine derivates;organic chemical;Building Blocks;C12 to C63;Carbonyl Compounds;Chemical Synthesis;Esters;Nutrition Research;Organic Building Blocks;Phytochemicals by Plant (Food/Spice/Herb);Vaccinium macrocarpon (Cranberry);CYSTADANE |
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Mol File: |
120-51-4.mol |
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Melting point |
18 °C |
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Boiling point |
323-324 °C(lit.) |
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density |
1.118 g/mL at 20 °C(lit.) |
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vapor pressure |
1 mm Hg ( 125 °C) |
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refractive index |
n20/D 1.568(lit.) |
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FEMA |
2138 | BENZYL BENZOATE |
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FEMA |
2797 | OCTANAL |
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Fp |
298 °F |
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storage temp. |
2-8°C |
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solubility |
Miscible with ethanol, alcohol, chloroform, ether, oils. |
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form |
Liquid |
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color |
Clear colorless |
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Water Solubility |
practically insoluble |
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JECFA Number |
24 |
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Merck |
14,1127 |
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BRN |
2049280 |
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Stability: |
Stable. Substances to be avoided include strong oxidizing agents. Combustible. |
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InChIKey |
SESFRYSPDFLNCH-UHFFFAOYSA-N |
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CAS DataBase Reference |
120-51-4(CAS DataBase Reference) |
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NIST Chemistry Reference |
Benzyl Benzoate(120-51-4) |
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EPA Substance Registry System |
Benzyl benzoate (120-51-4) |
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Hazard Codes |
Xn,N |
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Risk Statements |
22-51/53 |
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Safety Statements |
25-61-46 |
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RIDADR |
UN 3082 9 / PGIII |
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WGK Germany |
2 |
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RTECS |
DG4200000 |
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Autoignition Temperature |
896 °F |
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TSCA |
Yes |
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HazardClass |
9 |
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HS Code |
29163100 |
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Hazardous Substances Data |
120-51-4(Hazardous Substances Data) |
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Toxicity |
LD50 in rats, mice, rabbits, guinea pigs (g/kg): 1.7, 1.4, 1.8, 1.0 orally (Draize) |
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Description |
Benzyl benzoate (BnBzO) is a mediation and insect repellent. It is one of the older preparation used to treat scabies which is a skin infections caused by the mite scarcoptes scabiei since it is lethal to the mite. It is capable of killing the mite in 5 minutes. It can also be used for the treatment of lice infestation of the head and the body. Its mechanism of action is through exerting toxic effect on the nervous system of the insects, further causing its death. It is also toxic to mite ova through an unknown mechanism. It can also be used as a repellent for chiggers, ticks, and mosquitoes as well as a dye carrier, solvent of cellulose derivatives, plasticizer, and a fixative. |
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Description |
Benzyl benzoate is the ester of benzyl alcohol and benzoic acid, with the formula C6H5CH2O2CC6H5. This easily prepared compound with a mild balsamic odor has a variety of uses. |
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Chemical Properties |
Benzyl Benzoate is the main component of Peru balsam oil. It occurs in fairly large amounts in a number of blossom concretes and absolutes (e.g., tuberose and hyacinth). It forms either a viscous liquid or solid flakes (mp 21–22°C) and has a weak, sweet, balsamic odor. It is prepared either by transesterification of technical methyl benzoate with benzyl alcohol or from benzyl chloride and sodium benzoate. A third process starts with benzaldehyde, which is converted in high yield into benzyl benzoate in the presence of sodium or aluminum benzylate (Tishchenko reaction). Benzyl benzoate is used in perfumery as a fixative and as a modifier in heavy blossom fragrances. |
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Chemical Properties |
Colourless oily liquid with pleasant aromatic odour |
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Chemical Properties |
Benzyl benzoate is a clear, colorless, oily liquid with a slightly aromatic odor. It produces a sharp, burning sensation on the tongue. At temperatures below 178℃ it exists as clear, colorless crystals. |
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Chemical Properties |
Benzyl benzoate has a light, balsamic odor reminiscent of almond and a sharp, pungent taste. |
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Uses |
benzyl benzoate is an anti-microbial. It can also act as a solvent, helping dissolve other substances in the product, and as a perfuming ingredient. It is the ester of benzyl alcohol and benzoic acid. |
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Uses |
antiarteriosclerotic, hypolipaemic, hepatoprotectant |
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Uses |
Benzyl Benzoate has seen use as an insecticide, as well as a solvent for various chemical reactions. |
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Uses |
Used to kill lice and the mites responsible for the skin condition scabies. |
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Uses |
As solvent of cellulose acetate, nitrocellulose and artificial musk; substitute for camphor in celluloid and plastic pyroxylin Compounds; perfume fixative; in confectionery and chewing gum flavors. |
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Production Methods |
Benzyl benzoate is a constituent of Peru balsam and occurs naturally in certain plant species. Commercially, benzyl benzoate is produced synthetically by the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by the reaction of sodium benzylate with benzaldehyde. |
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Preparation |
By the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by reaction of sodium benzylate on benzaldehyde. |
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Brand name |
Pharmaceutic necessity for Dimercaprol [Injection]. Benylate (Sterling Winthrop). |
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Taste threshold values |
Taste characteristics at 30 ppm: balsamic, fruity with powdery and berry nuances. |
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Hazard |
Irritant to eyes, skin. |
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Contact allergens |
Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide. Direct contact may cause skin irritation, but rarely allergic contact dermatitis. As a fragrance allergen, benzyl benzoate has to be mentioned by name in EU cosmetics. |
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Chemical Synthesis |
This colorless liquid is formally the condensation product of benzoic acid and benzyl alcohol. It can also be generated from benzaldehyde by the Tishchenko reaction. |
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storage |
Benzyl benzoate is stable when stored in tight, well-filled, lightresistant containers. Exposure to excessive heat (above 408℃) should be avoided. |
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Incompatibilities |
Benzyl benzoate is incompatible with alkalis and oxidizing agents. |
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Regulatory Status |
Included in the FDA Inactive Ingredients Database (IM injections and oral capsules). Included, as an active ingredient, in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. |
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Raw materials |
Sodium-->Sodium carbonate-->Triethylamine-->Benzaldehyde-->Benzyl alcohol-->Benzoic acid-->Sodium benzoate-->Ethyl benzoate-->Peru balsam |
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Preparation Products |
3-Phenoxybenzyl alcohol-->2,6-Dichloroaniline-->4-Cyanophenol-->Batyl alcohol-->Butethamine-->Disperse Yellow 126 |
